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Psoriasis Information


Psoriasis Disease State Information

Psoriasis is a common, immune-mediated inflammatory disease that affects 2% to 3% of people worldwide.1-4 The most common manifestation—in 85% to 90% of cases—is plaque psoriasis.2-4 Approximately 20% of patients with plaque psoriasis suffer from moderate to severe disease, which can be associated with a high degree of clinical and psychosocial morbidity.3-6

Because plaque psoriasis is a systemic disorder, it may be associated with many well-established and emerging associated comorbidities including:

  • Psoriatic arthritis (PsA)4,6
  • Cardiovascular disease4,6,7
  • Crohn’s disease1
  • Diabetes mellitus (mainly type 2)6
  • Metabolic syndrome4,6,8
  • Obesity1,6
  • Lymphoma (although medications may contribute)1
  • Psychiatric disorders (eg, depression)3,4,6

The faculty of The Psoriasis PACT has assembled in-depth information on the systemic nature of moderate to severe plaque psoriasis, clinically important comorbidities and disease management approaches. Please explore the disease-related resources the faculty has prepared for you.

HCP Medical Education Slide Deck: Psoriasis Disease State

Get the most current thinking on psoriasis—all at once or one section at a time.

View the full deck

For a comprehensive review of psoriasis compiled by the experts of The Psoriasis PACT, read the full presentation.

Individual chapters may be downloaded below.

Introduction to psoriasis

Begin with an overview of the types and variants of psoriasis, including plaque psoriasis and its effect on health-related quality of life.

Histopathology of psoriasis

View micrographs of the morphological changes in psoriasis lesions at various stages of the disease.

Plaque psoriasis: immunology

Explore current concepts in the immunopathogenesis of psoriasis and the proinflammatory cycle underlying the disease.

Plaque psoriasis: comorbidities

Take a closer look at the potential systemic effects of psoriasis and associated comorbidities such as cardiovascular disease and psoriatic arthritis.

Epidemiology and genetics of plaque psoriasis

See data on the rising incidence and prevalence of psoriasis, plus estimates of genetic risk.

Assessing the severity of plaque psoriasis

Review 4 commonly used methods of assessing the severity of psoriasis.

Molecular pathways involved in psoriasis

Delve into the complex extracellular and intracellular pathways involved in psoriasis.



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